Ultrasmall Cu₂ZnSnS₄ (CZTS) nanocrystals with high near infrared (NIR) photothermal conversion abilities and peroxidase-mimic properties were synthesized and functionalized with bovine serum albumin (BSA) for rapid clearance multifunctional theranostic platform. Due to the presence of Cu (I) of CZTS@BSA, H₂O₂ could be decomposed to produce highly reactive oxygen species (ROS), catalyzed by intrinsic peroxidase like activity of CZTS. The CZTS@BSA possesses high NIR absorption and excellent photoacoustic (PA) imaging abilities. The as-prepared CZTS@BSA is also reported as an efficient T1 contrast agent for in vivo MR imaging. Therefore, in vivo distribution and rapid renal clearance of CZTS@BSA are successfully tracked by PA/MR dual-modal-imaging and further proved by ICP-MS analysis. Systemic acute toxicity evaluation indicates CZTS@BSA have good biocompatibility to normal tissues and blood. All results reveal that CZTS@BSA could act as a rapid clearance theranostic nanoplatform for dual-modal-imaging guided tumor PTT.

合成了具有高近红外（NIR）光热转换能力和过氧化物酶模拟特性的超小型Cu ₂ ZnSnS ₄（CZTS）纳米晶体，并用牛血清白蛋白（BSA）对其进行了功能化，以快速清除多功能治疗基因平台。由于CZTS @ BSA的Cu（I）的存在，H ₂ O ₂可以分解，产生CZTS固有的过氧化物酶活性，从而催化高活性氧（ROS）。CZTS @ BSA具有很高的近红外吸收率和出色的光声（PA）成像能力。如此制备的CZTS @ BSA也被报道为体内MR成像的有效T1造影剂。因此，体内PA / MR双模态成像成功地跟踪了CZTS @ BSA的分布和快速的肾脏清除，并通过ICP-MS分析进一步证明了这一点。全身急性毒性评估表明，CZTS @ BSA与正常组织和血液具有良好的生物相容性。所有结果表明，CZTS @ BSA可以作为双模态成像引导的肿瘤PTT的快速清除治疗学纳米平台。