SEE PAGE 53 A mong the different manifestations of peripheral arterial disease (PAD), atherosclerosis of lower extremity arteries is a major health threat that is undertreated, and poorly understood by the medical community (1). Population studies have estimated the prevalence of PAD around 4% in both Western Europe and U.S. populations (2,3). Individuals with symptomatic PAD display a high risk of cardiovascular morbidity and mortality. PAD is a complex multifactorial occlusive disorder and currently there is a paucity of mechanisms available to explain the underlying pathogenesis of the disease. Therefore, a limited innovative framework for the diagnosis and treatment of patients has been established (4). Pioneer studies highlight the contribution of circulating platelets as unexpected cellular entities involved in the pathogenesis of symptomatic atherosclerosis in coronary artery disease, cardiovascular disease, and PAD (5–7). The role of platelets in atherosclerosis-related disorders was restricted initially to thrombus formation upon rupture of advanced atherosclerotic plaques. This link to coronary artery disease and cardiovascular disease is easy, but the link to PAD is not straightforward. Indeed, the vast majority of patients with symptomatic PAD have a total

中文翻译：

---

MRP-14 宣扬外周动脉疾病中血小板和单核细胞联合的恶化*

参见第 53 页 在外周动脉疾病 (PAD) 的不同表现中，下肢动脉粥样硬化是一种主要的健康威胁，但未得到充分治疗，医学界对此知之甚少 (1)。人口研究估计，西欧和美国人群中 PAD 的患病率约为 4% (2,3)。有症状的 PAD 个体表现出心血管发病率和死亡率的高风险。PAD 是一种复杂的多因素闭塞性疾病，目前缺乏可用的机制来解释该疾病的潜在发病机制。因此，已经建立了用于患者诊断和治疗的有限创新框架（4）。先锋研究强调了循环血小板作为意外细胞实体的贡献，参与了冠状动脉疾病、心血管疾病和 PAD 中症状性动脉粥样硬化的发病机制 (5-7)。血小板在动脉粥样硬化相关疾病中的作用最初仅限于晚期动脉粥样硬化斑块破裂后的血栓形成。这种与冠状动脉疾病和心血管疾病的联系很容易，但与 PAD 的联系并不简单。事实上，绝大多数有症状的 PAD 患者的总 这种与冠状动脉疾病和心血管疾病的联系很容易，但与 PAD 的联系并不简单。事实上，绝大多数有症状的 PAD 患者的总 这种与冠状动脉疾病和心血管疾病的联系很容易，但与 PAD 的联系并不简单。事实上，绝大多数有症状的 PAD 患者的总