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Dopant-dependent crystallization and photothermal effect of Sb-doped SnO2 nanoparticles as stable theranostic nanoagents for tumor ablation†
Nanoscale ( IF 6.7 ) Pub Date : 2018-01-02 00:00:00 , DOI: 10.1039/c7nr08811f
Nuo Yu 1, 2, 3, 4, 5 , Chen Peng 6, 7, 8, 9, 10 , Zhaojie Wang 1, 2, 3, 4, 5 , Zixiao Liu 1, 2, 3, 4, 5 , Bo Zhu 1, 2, 3, 4, 5 , Zhigao Yi 11, 12, 13, 14 , Meifang Zhu 1, 2, 3, 4, 5 , Xiaogang Liu 11, 12, 13, 14 , Zhigang Chen 1, 2, 3, 4, 5
Affiliation  

Ideal theranostic nanoagents should be “all-in-one” type nanocrystals that have a single-semiconductor component and all-required properties (such as imaging and photothermal effects), but most semiconductor nanocrystals do not have these required properties. With SnO2 as a model of a typical wide-band semiconductor, we report the tuning from UV-responsive SnO2 to blue SnO2 nanocrystals with imaging ability and a Sb-doping-dependent photothermal effect. Sb-Doped SnO2 nanocrystals were prepared by heating SbCl3 and SnCl4 in benzyl alcohol solution through a facile solvothermal route. When the SbCl3/SnCl4 molar ratio increases from 0 to 0.2/1, the obtained samples exhibit an increased photothermal effect under the irradiation of a 1064 nm laser, accompanied by gradually decreased size and crystallinity. With a further increase of the molar ratio from 0.3/1.0 to 1.0/1.0, the resulting samples demonstrate the tetragonal SnO2 phase with amorphous-like compounds and they show no obvious enhancement of a photothermal effect. After a surface modification with biological molecules, the optimized Sb0.2-SnO2 nanocrystals demonstrated good stability and a high photothermal conversion efficiency of 48.3% as well as low cytotoxicity. When Sb0.2-SnO2 was injected into a tumor of mice, the tumor could be simultaneously detected by X-ray computed tomography (CT) and photoacoustic (PA) imaging, and then thermally ablated when exposed to a 1064 nm laser. Therefore, these nanocrystals can be used as “all-in-one” type nanoagents for imaging guided photothermal ablation of tumors under the irradiation of a laser in the second bio-transparent window.

中文翻译:

掺Sb的SnO 2纳米颗粒作为稳定的治疗肿瘤纳米剂的掺杂剂依赖性结晶和光热效应

理想的治疗药物纳米剂应为“多合一”型纳米晶体,具有单半导体成分和所有必需的特性(例如成像和光热效应),但大多数半导体纳米晶体不具备这些必需的特性。以SnO 2为典型宽带半导体的模型,我们报道了从具有UV响应的SnO 2到具有成像能力和依赖于Sb掺杂的光热效应的蓝色SnO 2纳米晶体的调谐过程。通过在苯甲醇溶液中通过简便的溶剂热途径加热SbCl 3和SnCl 4来制备掺Sb的SnO 2纳米晶体。当SbCl 3 / SnCl 4当摩尔比从0增加到0.2 / 1时,获得的样品在1064nm激光的照射下显示出增加的光热效应,同时伴随着尺寸和结晶度的逐渐减小。随着摩尔比从0.3 / 1.0进一步增加到1.0 / 1.0,所得样品显示出具有类似非晶形化合物的四方SnO 2相,并且它们没有显示出光热效应的明显增强。经过生物分子表面修饰后,优化的Sb 0.2 -SnO 2纳米晶体表现出良好的稳定性和48.3%的高光热转化效率以及低细胞毒性。当Sb 0.2 -SnO 2时将其注射到小鼠肿瘤中,可以通过X射线计算机断层扫描(CT)和光声(PA)成像同时检测肿瘤,然后在暴露于1064 nm激光时进行热消融。因此,这些纳米晶体可以用作“多合一”型纳米剂,用于在第二生物透明窗口中的激光照射下对肿瘤进行引导的光热消融成像。
更新日期:2018-01-02
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