Journal of Experimental Medicine ( IF 15.3 ) Pub Date : 2018-01-02 , DOI: 10.1084/jem.20170832 Christelle Harly 1 , Maggie Cam 2 , Jonathan Kaye 3, 4 , Avinash Bhandoola 1
Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.
中文翻译:
早期先天淋巴祖细胞的发育和分化
早先先天性淋巴祖细胞(EILP)最近已在小鼠成年骨髓中鉴定为针对先天性淋巴细胞(ILC)谱系指定的多能祖细胞,但它们与其他描述的ILC祖细胞的关系仍不清楚。在这项研究中,我们研究了EILP,全淋巴祖细胞(ALP)和ILC前体(ILCps)之间的祖先关系。功能,生物信息学,表型和遗传学方法共同将EILP确立为ALP和ILCps之间的中间祖先。我们的工作还为ILC开发提供了新的候选调节剂,并明确定义了早期ILC开发关键的转录因子需求阶段。