Purpose: Effective in vivo delivery of siRNA to silence genes is a highly sought-after goal in the treatment of multiple diseases. Cyclooxygenase-2 (COX-2) is a major mediator of inflammation and its effective and specific downregulation has been of major interest to treat conditions ranging from auto-immune diseases to gastric inflammation and cancer. Here we developed a novel and efficient method to produce a multiple imaging reporter labeled cationic dextran nanopolymer with cleavable positive charge groups for COX-2 siRNA delivery.

中文翻译：

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酸可降解的右旋糖酐作为图像指导的siRNA载体，用于COX-2下调

目的：有效体内递送siRNA以沉默基因是治疗多种疾病的高度追求的目标。环氧合酶2（COX-2）是炎症的主要介质，其有效和特异性下调对于治疗从自身免疫性疾病到胃部炎症和癌症的各种疾病具有重大意义。在这里，我们开发了一种新颖，有效的方法，以生产具有COX-2 siRNA传递可裂解正电荷基团的多重成像报告分子标记的阳离子葡聚糖纳米聚合物。