Background: Mucin1 (MUC1) is a highly glycosylated transmembrane protein that has gained attention because of its overexpression in various cancers. However, MUC1-targeted therapeutic antibodies have not yet been approved for cancer therapy. MUC1 is cleaved to two subunits, MUC1-N and MCU1-C. MUC1-N is released from the cell surface, making MUC1-C a more reasonable target for cancer therapy. Therefore, we produced a monoclonal antibody (anti-hMUC1) specific to the extracellular region of MUC1-C and evaluated its effects in vitro and in vivo.

中文翻译：

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Mucin1 C末端亚基定向单克隆抗体靶向乳腺癌中的Mucin1过表达。

背景： Mucin1（MUC1）是一种高度糖基化的跨膜蛋白，由于其在多种癌症中的过度表达而受到关注。但是，尚未将靶向MUC1的治疗性抗体批准用于癌症治疗。MUC1被切割为两个亚基，MUC1-N和MCU1-C。MUC1-N从细胞表面释放，使MUC1-C成为更合理的癌症治疗靶标。因此，我们产生了对MUC1-C细胞外区域具有特异性的单克隆抗体（抗-hMUC1），并评估了其在体内和体外的作用。