MicroRNAs (miRNAs) are short non-coding RNAs that regulate expression of target messenger RNAs (mRNAs) post-transcriptionally. Understanding the precise regulatory role of miRNAs is of great interest since miRNAs have been shown to play an important role in development, diseases, and other biological processes. Early work on miRNA target prediction has focused on static sequence-driven miRNA-mRNA complementarity. However, recent research also utilizes expression-level data to study context-dependent regulation effects in a more dynamic, physiologically-relevant setting.

中文翻译：

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Tiresias：上下文敏感的方法，以了解MicroRNA调控相互作用的存在和强度

MicroRNA（miRNA）是短的非编码RNA，可在转录后调节靶信使RNA（mRNA）的表达。由于miRNA已显示在发育，疾病和其他生物过程中起着重要作用，因此了解miRNA的精确调控作用引起了极大的兴趣。miRNA靶标预测的早期工作集中在静态序列驱动的miRNA-mRNA互补性上。然而，最近的研究还利用表达水平的数据来研究在更动态，生理相关的环境中的背景依赖性调节作用。