Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. The aim of this study was to use a model of early brain metastasis to evaluate the efficacy of α-emitting radionuclides, ¹⁴⁹Tb, ²¹¹At, ²¹²Pb, ²¹³Bi and ²²⁵Ac; β-emitting radionuclides, ⁹⁰Y, ¹⁶¹Tb and ¹⁷⁷Lu; and Auger electron (AE)-emitters ⁶⁷Ga, ⁸⁹Zr, ¹¹¹In and ¹²⁴I, for targeted radionuclide therapy (TRT).

中文翻译：

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VCAM-1靶向放射性核素治疗早期脑转移瘤的放射性核素剂量学评价

脑转移在乳腺癌患者中经常发生，并提出了紧迫的治疗挑战。血管细胞粘附分子1（VCAM-1）在转移早期在脑内皮细胞上的表达上调，为早期脑转移的检测和治疗提供了靶点。本研究的目的是使用早期脑转移模型来评估 α 发射放射性核素¹⁴⁹ Tb、²¹¹ At、²¹² Pb、²¹³ Bi 和²²⁵ Ac 的疗效；发射 β 的放射性核素，⁹⁰ Y、¹⁶¹ Tb 和¹⁷⁷ Lu；和俄歇电子 (AE) 发射器⁶⁷ Ga、⁸⁹ Zr、¹¹¹ In 和¹²⁴ I，用于靶向放射性核素治疗 (TRT)。