Seven new ophiobolins (1–5, 12, and 14) along with the 11 known analogues (6–11, 13, 15–18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4–8 and 11–15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC₅₀ values ranging from 0.6 to 9.5 μM.

中文翻译：

---

来自红树林真菌曲霉的蛇胆草

七个新ophiobolins（15，12，和14）与11个已知类似物沿（6 - 11，13，15 - 18）从红树真菌的液体和固体培养物中的乙酸乙酯提取物中分离焦曲霉094102通过光谱分析，化学方法和量子ECD计算，阐明了包括这七个新化合物的绝对构型在内的结构。化合物4 – 8和11 – 15对G3K，MCF-7，MD-MBA-231，MCF / Adr，A549和HL-60人癌细胞系显示出细胞毒性，IC ₅₀值为0.6至9.5μM。