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Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2017-12-29 , DOI: 10.1016/j.tibs.2017.12.003
Albert Serra-Cardona , Zhiguo Zhang

During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of histone chaperones as well as by histone-modifying enzymes. In recent years novel insights into nucleosome assembly of new H3–H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process. Moreover, in vitro reconstitution of chromatin replication has shed light on nucleosome assembly of parental H3–H4, a process that remains elusive. Finally, recent studies have revealed that the replication-coupled nucleosome assembly is important for the determination and maintenance of cell fate in multicellular organisms.



中文翻译:

表观遗传信息和细胞身份的传递中复制耦合的核小体大会。

在S期中,必须使用新合成的和亲本组蛋白将复制的DNA组装成核小体,该过程必须与DNA复制紧密结合。这种DNA复制偶联过程受多种组蛋白伴侣以及组蛋白修饰酶的调控。近年来,通过对经典组蛋白分子伴侣CAF-1的研究以及与这一过程有关的新因素的鉴定,获得了有关新型H3-H4四聚体核小体组装的新颖见解。而且,在体外染色质复制的重建为亲代H3-H4的核小体组装提供了线索,这一过程仍然难以捉摸。最后,最近的研究表明,复制偶联的核小体组装对于确定和维持多细胞生物中的细胞命运非常重要。

更新日期:2017-12-29
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