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One‐Pot Allan–Robinson/Friedländer Route to Chromen‐/Quinolin‐4‐ones through the Domino Acetylative Cyclisation of 2‐Hydroxy‐/2‐Aminobenzaldehydes
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-01-26 , DOI: 10.1002/ejoc.201701435
Vijai K. Rai 1 , Fooleswar Verma 1 , Ganeshwar P. Sahu 1 , Manorama Singh 1 , Ankita Rai 2
Affiliation  

A domino reaction between 2‐hydroxy‐/2‐aminobenzaldehydes and α‐haloketones gives chromen‐4‐ones and quinolin‐4‐ones in good to excellent yields. This method represents a new extension of the Allan–Robinson and Friedländer reactions, and uses N‐heterocyclic‐carbene catalysis. This approach has the advantages of operational simplicity, ambient reaction conditions, and no by‐product formation.
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中文翻译:

一锅Allan-Robinson /Friedländer路线通过2-羟基/ 2-氨基苯甲醛的多米诺乙酰化环化反应生成Chromen- / Quinolin-4-ones

2-羟基/ 2-氨基苯甲醛与α-卤代酮之间的多米诺反应使chromen-4-ones和quinolin-4-ones的产率高到极好。该方法代表了Allan-Robinson和Friedländer反应的新扩展,并使用了N-杂环-卡宾催化。这种方法的优点是操作简单,环境反应条件好,并且不会形成副产物。
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更新日期:2018-01-26
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