2H-Azirines are highly strained three-membered N-heterocycles, and their enantioselective synthesis is challenging. In their Communication on page 1039 ff., K. Okamoto, K. Ohe et al. report a novel enantioselective synthesis of 2H-azirines that is based on the transition-metal-catalyzed ring contraction of planar isoxazoles. The reaction is proposed to proceed through N−O bond cleavage of the isoxazoles followed by the formation of alkenylimide–rhodium intermediates to afford chiral 2-alkoxycarbonyl-2H-azirines with various substituents.

中文翻译：

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封底内层：通过异恶唑的对映选择性环收缩，不对称合成具有四取代的立体中心的2H-叠氮基（Angew。Chem。Int。Ed。4/2018）

2H-Azirines 是高度紧张的三元N-杂环，它们的对映选择性合成具有挑战性。在冈本K. Okamoto，K. Ohe等人在其第1039页及其后的通讯中。报道了基于平面异恶唑的过渡金属催化的环收缩的2 H-叠氮基的新型对映选择性合成。该反应提出通过异恶唑继之形成alkenylimide铑中间体，得到手性2-烷氧羰基的2 N-O键断裂进行ħ -azirines具有各种取代基。