Technetium (Tc) and Gadolinium (Gd) are the two most widely used metals in diagnostic medicine for scintigraphies and magnet resonance imaging (MRI), respectively. They play a crucial role for the generation or enhancement of contrast and are indispensable in countless diagnostic applications. However, the use of such contrast agents has caused severe health issues and environmental anomalies. This review aims to point out current issues and developments regarding the role and the analysis of these trace metals in medicine and the environment. Basic principles, issues and state of art of analytical methodologies are summarized. Current and future trends and the suggested implementation of novel methodologies and instrumentation are presented.

diagnostic（Tc）和Ga（Gd）分别是用于闪烁显像和磁共振成像（MRI）的诊断医学中最广泛使用的两种金属。它们对于产生或增强对比度起着至关重要的作用，并且在无数的诊断应用中必不可少。然而，使用这种造影剂已经引起严重的健康问题和环境异常。这篇综述旨在指出有关这些痕量金属在医学和环境中的作用和分析方面的当前问题和发展。总结了分析方法的基本原理，问题和最新技术。介绍了当前和未来的趋势以及新方法和仪器的建议实施方式。