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Immunometabolism in 2017: Metabolism and the inflammasome in health and ageing
Nature Reviews Endocrinology ( IF 40.5 ) Pub Date : 2017-12-29 , DOI: 10.1038/nrendo.2017.175
Thomas Mandrup-Poulsen

Immunometabolism in 2017: Metabolism and the inflammasome in health and ageing

Immunometabolism in 2017: Metabolism and the inflammasome in health and ageing, Published online: 29 December 2017; doi:10.1038/nrendo.2017.175

Extracellular danger-associated molecular patterns signal to NOD-like receptors, but the exact signalling pathways remain unclear. The inflammasomes, a subgroup of these receptors, translate danger signals into inflammatory responses by maturing IL-1 and IL-18. In 2017, researchers reported novel functions of the mutual interaction between metabolism and the inflammasomes in health and disease.


中文翻译:

2017年的免疫代谢:健康与衰老中的新陈代谢和炎症小体

2017年的免疫代谢:健康与衰老中的新陈代谢和炎症小体

《 2017年免疫代谢:健康与衰老中的代谢与炎症小体》,在线发布:2017年12月29日; doi:10.1038 / nrendo.2017.175

细胞外危险相关分子模式向NOD样受体发出信号,但确切的信号传导途径仍不清楚。炎性小体是这些受体的一个亚类,通过使IL-1和IL-18成熟,将危险信号转化为炎症反应。2017年,研究人员报告了新陈代谢与炎性小体之间相互作用的新功能在健康和疾病中的作用。
更新日期:2017-12-31
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