A biomass-based magnetic fluorescent nanoparticle (MFNPs) was successively in situ synthesized via a one-step high-gravity approach, which constructed by a magnetic core of Fe₃O₄ nanoparticles, the fluorescent marker of carbon dots (CDs), and shells of chitosan (CS). The obtained MFNPs had a 10 nm average diameter and narrow particle size distribution, low cytotoxicity, superior fluorescent emission and superparamagnetic properties. The encapsulating and release 5-fluorouracil experiments confirmed that the introduction of CS/CDs effectively improved the drug loading capacity. Mechanism and kinetic studies proved that: (i) the monolayer adsorption was the main sorption mode under the studied conditions; (ii) the whole adsorption process was controlled by intra-liquid diffusion mass transfer and governed by chemisorption; and (iii) the release process is controlled by Fickian diffusion. These results demonstrated this method to one-step continuously produce MFNPs and the construction of non-toxic nanostructure possessed great superiority in currently NDS, which would show high application value in targeted drug delivery, magnetic fluid hyperthermia treatment, magnetic resonance imaging (MRI), in vitro testing and relative research.

采用Fe ₃ O ₄磁芯通过一步高重力法原位合成了生物质基磁性荧光纳米颗粒（MFNPs）。纳米颗粒，碳点（CD）的荧光标记和壳聚糖（CS）的壳。所获得的MFNP具有10nm的平均直径和窄的粒度分布，低的细胞毒性，优异的荧光发射和超顺磁性质。包封和释放5-氟尿嘧啶的实验证实，CS / CD的引入有效地提高了载药量。机理和动力学研究证明：（i）在所研究的条件下，单层吸附是主要的吸附方式；（ii）整个吸附过程由液体内扩散传质控制，并受化学吸附作用控制；（iii）释放过程由菲克扩散控制。体外测试和相关研究。