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A novel synthesis of aryl methyl sulfones and β-hydroxysulfones from sodium sulfinates and di-tert-butyl peroxide in H2O medium
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2017-12-29 , DOI: 10.1016/j.tetlet.2017.12.074
Junyi Lai , Gaoqing Yuan

A novel and convenient synthetic route for aryl methyl sulfones and β-hydroxysulfones was developed via the radical reaction between sodium sulfinates and di-tert-butyl peroxide (DTBP). Without any catalysts and additives, the synthetic process could be smoothly carried out to afford the target products in good to excellent yields in H2O medium, demonstrating its promising application. In the present system, H2O could act not only as a green solvent but also as a reactant.



中文翻译:

芳基甲基砜和的一种新颖的合成β -hydroxysulfones选自钠亚磺酸盐和二-叔-丁基过氧化物H中2 ö介质

通过亚磺酸钠与二叔丁基过氧化物(DTBP)之间的自由基反应,开发了一种新颖,便捷的芳基甲基砜和β-羟基砜合成路线。在没有任何催化剂和添加剂的情况下,可以顺利进行合成过程,从而在H 2 O介质中以良好或优异的收率得到目标产物,这证明了其有希望的应用。在本系统中,H 2 O不仅可以充当绿色溶剂,而且可以充当反应物。

更新日期:2017-12-29
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