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Facile preparation of Eu3+ and F− co-doped luminescent hydroxyapatite polymer composites via the photo-RAFT polymerization
Journal of the Taiwan Institute of Chemical Engineers ( IF 5.7 ) Pub Date : 2017-12-29 , DOI: 10.1016/j.jtice.2017.12.006
Long Huang , Weihua Luo , Meiying Liu , Jianwen Tian , Qiang Huang , Hongye Huang , Junfeng Hui , Yuanqing Wen , Xiaoyong Zhang , Yen Wei

The luminescent hydroxyapatite nanorods co-doped with Eu3+ and F (named as FAp:Eu3+) were synthesized through liquid-solid-solution strategy to control their size and morphology as well as improve their fluorescence. However, these luminescent FAp:Eu3+nanorods are hydrophobic nature and cannot be directly used for biomedical applications. In this work, we developed a novel strategy for surface modification of FAp:Eu3+nanorods with the combination of the surface ligand exchange reaction and photo-initiated reversible addition-fragmentation chain transfer (photo-RAFT) polymerization using the biocompatible and hydrophilic poly(ethylene glycol) methacrylate (PEGMA) as the monomer. We demonstrated that the photo-RAFT polymerization is a facile and efficient route to fabricate hydrophilic FAp:Eu3+-polyPEGMA composites based on a series of characterization techniques. The FAp:Eu3+-polyPEGMA composites still well maintained the morphology and luminescent properties. Furthermore, the resultant FAp:Eu3+-polyPEGMA composites showed low cytotoxicity and desirable cell uptake behavior. These features suggested that the FAp:Eu3+-polyPEGMA composites are of great potential for biological imaging applications. More importantly, the photo-RAFT polymerization should be promising for preparation of many other luminescent nanocomposites owing to their advantages of photo-RAFT polymerization such as low polymerization temperature, high efficiency, absence of metal catalysts and good monomer applicability. It is therefore, the photo-RAFT could be extended for fabrication of many other multifunctional fluorescent composites for different biomedical applications.



中文翻译:

铕的简易制备3+和F -共掺杂的发光羟基磷灰石聚合物复合材料通过光RAFT聚合

发光羟基磷灰石纳米棒共掺杂有Eu 3+和F - (命名为FAP:Eu的3+)通过液体-固体-溶液策略合成,以控制它们的尺寸和形态,以及提高它们的荧光。但是,这些发光的FAp:Eu 3+纳米棒具有疏水性,不能直接用于生物医学应用。在这项工作中,我们为FAp:Eu 3+的表面改性开发了一种新的策略纳米棒结合了表面配体交换反应和光引发的可逆加成-断裂链转移(photo-RAFT)聚合,并使用了生物相容性和亲水性的聚乙二醇(甲基丙烯酸甲酯)(PEGMA)作为单体。我们证明了光-RAFT聚合是基于一系列表征技术制造亲水性FAp:Eu 3+ -polyPEGMA复合材料的便捷有效途径。FAp:Eu 3+ -polyPEGMA复合材料仍然很好地保持了形态和发光性能。此外,所得的FAp:Eu 3+ -polyPEGMA复合材料显示出低细胞毒性和所需的细胞摄取行为。这些功能表明FAp:Eu 3+-polyPEGMA复合材料在生物成像应用中具有巨大潜力。更重要的是,由于光-RAFT聚合的低聚合温度,高效率,无金属催化剂和良好的单体适用性等优点,光-RAFT聚合应有望用于制备许多其他发光纳米复合材料。因此,可以将光-RAFT扩展用于制造许多其他用于不同生物医学应用的多功能荧光复合材料。

更新日期:2017-12-29
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