The condensation of dimethylallyl diphosphate and geranyl diphosphate is catalyzed by isosesquilavandulyl diphosphate synthase (mcl22) from Streptomyces CNH-189 through a recently classified head-to-middle mechanism, producing a precursor of novel merochlorin-class antibiotics. In their Communication on page 683 ff., R.-T. Guo et al. present crystal structures of mcl22 in complex with substrate analogues. Mcl22 forms an unprecedented pocket to accommodate the allylic substrate.

中文翻译：

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封底内页：“头到中间”和“头到尾”顺式-戊二烯基转移酶：异麦芽酰香叶酰二磷酸二磷酸合酶的结构（Angew。Chem。Int。Ed。3/2018）

链霉菌CNH-189的 异戊烯二醛二磷酸合酶（mcl22）通过最近分类的从头到中的机理催化二甲基烯丙基二磷酸酯和香叶基二磷酸酯的缩合反应，从而生产出新的甲绿素类抗生素的前体。R.-T.在其第683页及以下的通讯中。郭等。提出了与底物类似物复合的mcl22的晶体结构。Mcl22形成了史无前例的口袋，可容纳烯丙基底物。