Gene therapy provides a novel method for cancer therapy. This study shows a DNA nanocomplex that is inspired from vesicular stomatitis virus (VSV) for ovarian cancer therapy. This DNA nanocomplex consists of a cationized monomethoxy poly (ethylene glycol)‐poly (d,l‐lactide) (MPEG‐PLA) nanoparticle and a plasmid encoding the matrix protein of vesicular stomatitis virus (VSVMP) that plays a critical role in the VSV‐induced apoptosis of cancer cells. The cationized MPEG‐PLA nanoparticle that is self‐assembled by MPEG‐PLA copolymer and N‐[1‐(2,3‐dioleoyloxy) propyl]‐N,N,N‐trimethylammonium chloride (DOTAP) has low cytotoxicity and high transfection efficiency (>80%). Intraperitoneal administration of the pVSVMP nanocomplex remarkably inhibits the intraperitoneal metastasis of ovarian cancer and does not cause significant systemic toxicity. The apoptosis induction and anti‐angiogenesis are involved in the anticancer mechanism. This work demonstrates a VSV‐inspired DNA nanocomplex that has potential application for the treatment of intraperitoneal metastasis of ovarian cancer.

中文翻译：

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水泡性口炎病毒启发的 DNA 纳米复合物用于卵巢癌治疗

基因治疗为癌症治疗提供了一种新方法。这项研究展示了一种受水泡性口炎病毒 (VSV) 启发的 DNA 纳米复合物，用于卵巢癌治疗。这种 DNA 纳米复合物由阳离子化单甲氧基聚（乙二醇）-聚（d,l-丙交酯）（MPEG-PLA）纳米颗粒和编码水泡性口炎病毒（VSVMP）基质蛋白的质粒组成，该蛋白在 VSV 中发挥着关键作用‐诱导癌细胞凋亡。由MPEG-PLA共聚物和N- [1-(2,3-二油酰氧基)丙基]-N ,N,N-三甲基氯化铵(DOTAP)自组装的阳离子化MPEG-PLA纳米粒子具有低细胞毒性和高转染效率(>80%)。p VSVMP纳米复合物腹膜内给药显着抑制卵巢癌的腹膜内转移，并且不会引起明显的全身毒性。细胞凋亡诱导和抗血管生成参与抗癌机制。这项工作展示了一种受 VSV 启发的 DNA 纳米复合物，具有治疗卵巢癌腹膜内转移的潜在应用。