The formal total syntheses of (−)-actinophyllic acid and its enantiomer starting from the same chiral intermediate are reported. The synthesis features a photoredox organocatalytic asymmetric alkylation to generate the original C15 chirality, a photocatalytic C–H functionalization of 3-methylindole in flow for constructing the C16 all-carbon quaternary center, a regioselective 1,3-dipolar cycloaddition, and an intramolecular Henry reaction to assemble the pentacyclic core of the target molecule.

中文翻译：

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（-）-和（+）-猕猴桃酸的形式总合成

据报道，从相同的手性中间体开始，（-）-放线菌酸及其对映异构体的正式全部合成。该合成具有光氧化还原有机催化不对称烷基化以产生原始的C15手性，3-甲基吲哚的光催化C–H官能化以构建C16全碳四元中心，区域选择性的1,3-偶极环加成和分子内亨利反应以组装靶分子的五环核。