Among Lysobacter species, Lysobacter antibioticus has been demonstrated to be an interesting source of antimicrobial metabolites for the biocontrol of plant diseases. Although the antibacterial activity was attributed to N-oxide phenazines, the active compounds involved in the antifungal function remained unknown. In this work, an antifungal compound was isolated and identified as p-aminobenzoic acid (pABA). Antifungal activity screening revealed that pABA shows activity against a number of plant pathogens. The genes involved in the synthetic route of this compound in OH13 were identified. Further, the production of pABA was optimized by modification of the carbon source using engineered L. antibioticus OH13 strains.

中文翻译：

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抗生素溶杆菌OH13中抗真菌对氨基苯甲酸的产生

在溶杆菌属中，已证明抗生素溶杆菌是用于植物病害生物防治的抗菌代谢物的有趣来源。尽管抗菌活性归因于N-氧化物吩嗪，但涉及抗真菌功能的活性化合物仍是未知的。在这项工作中，分离出一种抗真菌化合物，并将其鉴定为对氨基苯甲酸（pABA）。抗真菌活性筛选显示，pABA显示出对多种植物病原体的活性。鉴定了该化合物在OH13中合成途径中涉及的基因。此外，pABA的生产通过使用工程化的L.抗生素改造碳源来优化。 OH13菌株。