The C57BL/6J mice were fed a 135-day normal diet or a high-fat diet (HFD) without, or concurrent with, a single yam dioscorin (80 mg/kg) or dipeptide NW (40 mg/kg) intervention every day. The final body weights (g) of mice were 26.1 ± 1.4, 34.97 ± 2.1, 31.75 ± 2.6, and 31.66 ± 3.1, respectively, for normal diet-fed, HFD-fed, dioscorin-intervened, and NW-intervened group. The mice in both intervened groups showed similar less weight gains and had significant differences (P < 0.05) compared to those in the HFD group under the same cumulative HFD intakes. The blood biochemical index of mice with dioscorin interventions showed significantly lower contents in total cholesterol and low-density lipoprotein, and NW interventions showed significantly lower total triglyceride contents compared to those of the HFD group (P < 0.05). Both intervened mice exhibited similar reductions in total visceral lipid contents and have significant differences compared to those of the HFD group (P < 0.05). The dioscorin intervention was better than NW interventions in lowering blood glucose levels by oral glucose tolerance tests and both showed significant differences (P < 0.05) compared to those in the HFD group. Yam dioscorin or dipeptide NW will potentially be used for preventive functional foods of less body weight gains and impaired glucose tolerance controls, which require further clinical trial investigations.

中文翻译：

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135天山药薯os皂甙和二肽Asn-Trp（NW）干预可减少体重增加并改善高脂饮食诱导的C57BL / 6小鼠的糖耐量受损

每天给C57BL / 6J小鼠喂食135天的正常饮食或高脂饮食（HFD），而无需干预或与之配合的是单独的山药dioscorin（80 mg / kg）或二肽NW（40 mg / kg）干预。对于正常饮食喂养，HFD喂养，川sco呤干预和NW干预组，小鼠的最终体重（g）分别为26.1±1.4、34.97±2.1、31.75±2.6和31.66±3.1。两组干预组的小鼠体重增加相似，差异显着（P<0.05）与相同的HFD累积摄入量下的HFD组相比。与高脂饮食组相比，经地高辛干预的小鼠的血液生化指标显示总胆固醇和低密度脂蛋白含量明显降低，而西北部干预的总甘油三酯含量明显降低（P <0.05）。与HFD组相比，两只干预小鼠的总内脏脂质含量均表现出相似的降低，并且具有显着差异（P <0.05）。该dioscorin干预比NW干预措施更好地通过口服葡萄糖耐量试验，并都显示显著差异降低血糖水平（P<0.05）与HFD组相比。薯dio皂甙或二肽NW可能会用于体重增加较少和糖耐量控制受损的预防性功能食品，这需要进一步的临床试验研究。