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Rational Design, Binding Studies, and Crystal‐Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14‐3‐3ζ Adapter Protein
ChemBioChem ( IF 3.2 ) Pub Date : 2018-02-15 , DOI: 10.1002/cbic.201700588
Martin Ehlers 1 , Jean-Noël Grad 2 , Sumit Mittal 3 , David Bier 4 , Marcel Mertel 1 , Ludwig Ohl 2 , Maria Bartel 4, 5 , Jeroen Briels 4, 5 , Marius Heimann 1 , Christian Ottmann 4, 5 , Elsa Sanchez-Garcia 3 , Daniel Hoffmann 2 , Carsten Schmuck 1
Affiliation  

To be where no one has ever been before: By combining supramolecular chemistry with rational in silico design, we find the first small molecule binding to the dimerisation interface of the 14‐3‐3ζ adapter protein, a key player for intracellular communication.
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中文翻译:

针对14-3-3ζ衔接子蛋白二聚体界面的第一个配体的合理设计,结合研究和晶体结构评估

前所未有的发展:通过将超分子化学与合理的计算机设计相结合,我们发现了第一个小分子与14-3-3ζ衔接子蛋白的二聚化界面结合,后者是细胞内通讯的关键参与者。
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更新日期:2018-02-15
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