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Nanocarrier‐Mediated Photochemotherapy and Photoradiotherapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-12-28 , DOI: 10.1002/adhm.201701211
Antonia G. Denkova 1 , Robine M. de Kruijff 1 , Pablo Serra‐Crespo 1
Affiliation  

Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treatments. However, most preclinical studies show that complete elimination of tumors is rarely observed. Combining PDT and PTT with chemotherapy or radiotherapy can improve the therapeutic outcome and simultaneously decrease side effects of these conventional treatments. Nanocarriers can help to facilitate such a combined treatment. Here, the most recent advancements in the field of photochemotherapy and photoradiotherapy, in which nanocarriers are employed, are reviewed.

中文翻译:

纳米载体介导的光化学疗法和光放射疗法

光热疗法(PTT)和光动力疗法(PDT)都利用光来诱导治疗效果。由于光的非侵入性以及与这些治疗相关的有限的副作用,这些疗法迅速变得越来越重要。但是,大多数临床前研究表明,很少观察到肿瘤的完全消除。将PDT和PTT与化学疗法或放射疗法相结合可以改善治疗效果,同时减少这些常规治疗方法的副作用。纳米载体可以帮助促进这种联合治疗。在此,对使用纳米载体的光化学疗法和光放射疗法领域的最新进展进行了综述。
更新日期:2017-12-28
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