Light responsive materials play an important role in many biomedical applications. Despite the great potential, commonly available systems are limited by their toxicity and lack of biodegradability. Here, an efficient light triggered system from safe, biodegradable star-poly(ethylene glycol) (star-PEG) and poly(ε-caprolactone) (PCL) with varying melting points controlled by the length of the CL segments is described. When incorporated with gold nanoshells (GNS) and exposed to near-infrared (NIR) irradiation, matrices temporarily disengage, thus allowing efficient on-demand healing and drug release. The responsiveness of this system to light, with its tailorable physical and healing properties, biocompatibility, biodegradability, and the capability to incorporate drugs and on-demand drug release are all desirable traits for numerous clinical applications.

中文翻译：

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近红外光诱导的可生物降解复合材料的按需愈合和药物释放的相变。

光敏材料在许多生物医学应用中起着重要作用。尽管潜力巨大，但通用系统仍受其毒性和缺乏生物降解性的限制。在此，描述了一种有效的光触发系统，该系统由安全，可生物降解的星形聚乙二醇（star-PEG）和聚（ε-己内酯）（PCL）组成，其熔点受CL段长度的控制而变化。当与金纳米壳（GNS）结合并暴露于近红外（NIR）辐射时，基质会暂时脱离，从而实现高效的按需愈合和药物释放。该系统对光的响应能力，以及可定制的物理和愈合特性，生物相容性，生物降解性，