Synaptic plasticity contributes to behavioral adaptations. As a key node in the reward pathway, the nucleus accumbens (NAc) is important for determining motivation-to-action outcomes. Across animal models of motivation including addiction, depression, anxiety, and hedonic feeding, selective recruitment of neuromodulatory signals and plasticity mechanisms have been a focus of physiologists and behaviorists alike. Experience-dependent plasticity mechanisms within the NAc vary depending on the distinct afferents and cell-types over time. A greater understanding of molecular mechanisms determining how these changes in synaptic strength track with behavioral adaptations will provide insight into the process of learning and memory along with identifying maladaptations underlying pathological behavior. Here, we summarize recent findings detailing how changes in NAc synaptic strength and mechanisms of plasticity manifest in various models of motivational disorders.

中文翻译：

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伏隔核中的突触可塑性：从经验中学到的教训。

突触可塑性有助于行为适应。作为奖励途径中的关键节点，伏隔核（NAc）对于确定动机到行动的结果很重要。在包括成瘾，抑郁，焦虑和享乐喂养在内的各种动机模型中，神经调节信号和可塑性机制的选择性募集一直是生理学家和行为主义者关注的焦点。NAc中依赖于经验的可塑性机制会随着时间的推移而随传入和细胞类型的不同而变化。对分子机制的更多了解将决定突触强度的这些变化如何随行为适应而变化，这将提供对学习和记忆过程的洞察力，并识别出病理行为背后的适应不良。这里，