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Design and Structure–Function Characterization of 3D Printed Synthetic Porous Biomaterials for Tissue Engineering
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-12-27 , DOI: 10.1002/adhm.201701095
Cambre N. Kelly 1 , Andrew T. Miller 1 , Scott J. Hollister 2 , Robert E. Guldberg 3 , Ken Gall 1
Affiliation  

3D printing is now adopted for use in a variety of industries and functions. In biomedical engineering, 3D printing has prevailed over more traditional manufacturing methods in tissue engineering due to its high degree of control over both macro‐ and microarchitecture of porous tissue scaffolds. However, with the improved flexibility in design come new challenges in characterizing the structure–function relationships between various architectures and both mechanical and biological properties in an assortment of clinical applications. Presently, the field of tissue engineering lacks a comprehensive body of literature that is capable of drawing meaningful relationships between the designed structure and resulting function of 3D printed porous biomaterial scaffolds. This work first discusses the role of design on 3D printed porous scaffold function and then reviews characterization of these structure–function relationships for 3D printed synthetic metallic, polymeric, and ceramic biomaterials.

中文翻译:

用于组织工程的3D打印合成多孔生物材料的设计和结构-功能表征

现在已将3D打印用于各种行业和功能。在生物医学工程中,由于3D打印对多孔组织支架的宏观和微观结构都具有高度的控制能力,因此在组织工程中已经超越了传统的制造方法。然而,随着设计灵活性的提高,在各种临床应用中表征各种体系结构之间的结构-功能关系以及机械和生物学特性方面提出了新的挑战。当前,组织工程领域缺乏能够在3D打印的多孔生物材料支架的设计结构与最终功能之间绘制有意义关系的综合文献。
更新日期:2017-12-27
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