Biomaterials are key factors in regenerative medicine. Matrices used for cell delivery are especially important, as they provide support to transplanted cells that is essential for promoting cell survival, retention, and desirable phenotypes. Injectable matrices have become promising and attractive due to their minimum invasiveness and ease of use. Conventional injectable matrices mostly use hydrogel precursor solutions that form solid, cell‐laden hydrogel scaffolds in situ. However, these materials are associated with challenges in biocompatibility, shear‐induced cell death, lack of control over cellular phenotype, lack of macroporosity and remodeling, and relatively weak mechanical strength. This Progress Report provides a brief overview of recent progress in developing injectable matrices to overcome the limitations of conventional in situ hydrogels. Biocompatible chemistry and shear‐thinning hydrogels have been introduced to promote cell survival and retention. Emerging investigations of the effects of matrix properties on cellular function in 3D provide important guidelines for promoting desirable cellular phenotypes. Moreover, several novel approaches are combining injectability with macroporosity to achieve macroporous, injectable matrices for cell delivery.

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开发可注射基质以增强细胞输送和组织再生的最新进展

生物材料是再生医学的关键因素。用于细胞递送的基质尤其重要，因为它们为移植细胞提供支持，这对于促进细胞存活、保留和理想的表型至关重要。可注射基质由于其侵入性最小且易于使用而变得有前途且有吸引力。传统的可注射基质大多使用水凝胶前体溶液，在原位形成固体、充满细胞的水凝胶支架。然而，这些材料存在生物相容性、剪切诱导的细胞死亡、缺乏对细胞表型的控制、缺乏大孔隙和重塑以及相对较弱的机械强度等方面的挑战。本进展报告简要概述了开发可注射基质以克服传统原位水凝胶局限性的最新进展。生物相容性化学和剪切稀化水凝胶已被引入以促进细胞存活和保留。基质特性对 3D 细胞功能影响的新兴研究为促进理想的细胞表型提供了重要指导。此外，一些新方法将可注射性与大孔性相结合，以获得用于细胞递送的大孔可注射基质。