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Cucurbitane-type triterpenes from the tubers of Hemsleya penxianensis and their bioactive activity
Phytochemistry ( IF 3.8 ) Pub Date : 2018-03-01 , DOI: 10.1016/j.phytochem.2017.12.014
Nailiang Zhu , Zhonghao Sun , Meigeng Hu , Yedan Li , Dawei Zhang , Haifeng Wu , Yu Tian , Pengfei Li , Junshan Yang , Guoxu Ma , Xudong Xu

The tubers of the medicinal plant Hemsleya penxianensis (Cucurbitaceae) yielded 11 cucurbitane-type triterpenes Xuedanencins A-K by silica gel column, ODS column, and pre-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Separated compounds were evaluated for cytotoxic activity against the Hela human cancer cell line and compounds 7 and 8 showed significant cytotoxicity with IC50 values at 1.82 and 2.45 μM, respectively.

中文翻译:

彭县红木块茎中葫芦素型三萜类化合物及其生物活性

通过硅胶柱、ODS 柱和预 HPLC 技术,药用植物 Hemsleya penxianensis (Cucurbitaceae) 的块茎产生了 11 种葫芦型三萜类 Xuedanncins AK。它们的结构是通过光谱分析确定的,并与先前研究的现有数据一起检查。评估了分离的化合物对 Hela 人癌细胞系的细胞毒性活性,化合物 7 和 8 显示出显着的细胞毒性,IC50 值分别为 1.82 和 2.45 μM。
更新日期:2018-03-01
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