The highly efficient selective monohydrolysis reaction we previously reported has been applied to monohydrolysis of several bulkyl symmetric diesters, including diethyl esters, dipropyl esters, and dibutyl esters. A greater proportion of a polar aprotic co-solvent, DMSO, and aqueous KOH appear to help improve the reactivity of bulky diesters compared to the corresponding dimethyl esters. The procedure is mild and practical, yielding the corresponding half-esters in high yields under simple conditions.

中文翻译：

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实用的大体积对称二酯选择性单水解

我们先前报道的高效选择性单水解反应已应用于几种大体积对称双酯的单水解反应，包括二乙酯，二丙酯和二丁酯。与相应的二甲基酯相比，更大比例的极性非质子助溶剂，DMSO和KOH水溶液似乎有助于改善大体积二酯的反应性。该过程是温和且实用的，在简单条件下以高收率得到相应的半酯。