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Practical synthesis of two novel series of 1,3-disubstituted β-carboline derivatives
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2017-12-23 , DOI: 10.1016/j.tetlet.2017.12.063
Péter Ábrányi-Balogh , Balázs Volk , Mátyás Milen

The synthesis of two novel series of 1,3-disubstituted β-carbolines from 1-aryl-β-carboline-3-carbaldehyde building blocks is reported. In the first case, an efficient synthesis of 1-aryl-β-carboline C-3 tethered tetrahydro-imidazopyridines and their aromatic counterparts was developed. In the second case, the Willgerodt-Kindler three-component reaction was used for the transformation of aldehydes into the corresponding thioamides.



中文翻译:

实用合成两个新的系列的1,3-二取代的β-咔啉衍生物

报道了从1-芳基-β-咔啉-3-甲醛的构建基合成两个新颖的1,3-二取代的β-咔啉系列。在第一种情况下,开发了1-芳基-β-咔啉C-3束缚的四氢-咪唑并吡啶及其芳族对应物的有效合成方法。在第二种情况下,使用Willgerodt-Kindler三组分反应将醛转化为相应的硫代酰胺。

更新日期:2017-12-23
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