Racemic Δ²‐pyrrolin‐4‐ones (i. e. 4‐pyrrolones), easily available in two steps from N‐protected α‐amino acids, undergo organocatalysed asymmetric Mannich‐type addition to isatin‐derived ketimines to furnish the non‐racemic oxindole‐Δ²‐pyrrolin‐4‐one adducts, stereoselectively (up to 96% ee, dr≥15:1). The oxindole–pyrrolone products feature vicinal tetrasubstituted carbon stereocenters. The developed protocol has a broad substrate scope and tolerates diverse substituents at position C‐5 in 4‐pyrrolones and at positions N‐1 and C‐5/7 in isatin imines.

中文翻译：

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通过Mannich型有机催化将Δ2-吡咯啉-4-酮加到Isatin亚胺上来构建四联取代的立体立体中心

外消旋Δ ² -吡咯啉-4-酮（即4-吡咯酮类）中，从两个步骤容易获得ñ -保护的α -氨基酸，离岗organocatalysed不对称曼尼希型除靛红衍生的酮亚胺，得到非外消旋的羟吲哚-Δ ² -吡咯啉-4-酮加合物，立体选择性（高达96％ee值，博士≥15：1）。羟吲哚-吡咯烷酮产品具有邻近的四取代碳立体中心。所开发的方案具有广泛的底物范围，并且可以耐受4-吡咯烷酮中C-5位置以及异亚胺中N-1和C-5 / 7位置的各种取代基。