The transient activation of function using chemical fuels is common in nature, but much less in synthetic systems. Progress towards the development of systems with a complexity similar to that of natural ones requires chemical fuel selectivity. Here, we show that a self‐assembled nanosystem, composed of monolayer‐protected gold nanoparticles and a fluorogenic peptide, is activated for transient signal generation only in case the chemical fuel matches the recognition site present at the nanoparticle surface. A modification of the recognition site in the nanosystem completely changes the chemical fuel selectivity. When two nanosystems are simultaneously present, the selectivity expressed by the system depends on the concentration of nucleotide added.

中文翻译：

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纳米系统的燃料选择性瞬态激活，用于产生信号。

使用化学燃料进行功能的瞬态激活在自然界中很常见，但在合成系统中则少得多。复杂性与天然系统相似的系统开发需要化学燃料选择性。在这里，我们表明只有在化学燃料与纳米颗粒表面上存在的识别位点相匹配的情况下，由单层保护的金纳米颗粒和荧光肽组成的自组装纳米系统才被激活以产生瞬态信号。纳米系统中识别位点的修饰完全改变了化学燃料的选择性。当同时存在两个纳米系统时，系统表达的选择性取决于所添加核苷酸的浓度。