Abstract A new, simple and highly sensitive method of dexamethasone (DM) voltammetric determination was successfully developed. Low limit of detection has been obtained using amalgam film silver based electrode (Hg(Ag)FE) as the working electrode. The electrochemical behaviour of dexamethasone reduction on Hg(Ag)FE was investigated using cyclic voltammetry. A linear voltammetric response was obtained for DM in the concentration range from 2.50·10− 9 mol L− 1 (9.16·10− 7 g L− 1) to 2.25·10− 7 mol L− 1 (8.83·10− 5 g L− 1), with a detection limit of 1.6·10− 9 mol L− 1 for preconcentration time of 45 s. Repeatability of method was determined as RSD % for dexamethasone concentration of 0.1·10− 6 mol L− 1 as 1.6% (n = 5). The proposed method was successfully applied and validated by studying the recovery of dexamethasone in commercially available drugs.

中文翻译：

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汞齐薄膜电极上地塞米松的高灵敏度伏安法测定

摘要 成功开发了地塞米松（DM）伏安法测定新方法，操作简便，灵敏度高。使用汞合金薄膜银基电极 (Hg(Ag)FE) 作为工作电极已获得低检测限。使用循环伏安法研究地塞米松还原对 Hg(Ag)FE 的电化学行为。在 2.50·10− 9 mol L− 1 (9.16·10− 7 g L− 1) 到 2.25·10− 7 mol L− 1 (8.83·10− 5 g L− 1)，预浓缩时间为 45 s 时的检测限为 1.6·10− 9 mol L− 1。方法的重复性被确定为地塞米松浓度为 0.1·10− 6 mol L− 1 时的 RSD % 为 1.6% (n = 5)。通过研究地塞米松在市售药物中的回收率，该方法得到了成功应用和验证。