当前位置: X-MOL 学术Nano Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery
Nano Research ( IF 9.9 ) Pub Date : 2018-08-02 , DOI: 10.1007/s12274-017-1939-y
Yiru Wang , Tinghui Yin , Zhenwei Su , Chen Qiu , Yong Wang , Rongqin Zheng , Meiwan Chen , Xintao Shuai

Although gas-filled microbubbles with high echogenicity are widely applied inclinical ultrasonography, the micron scale particle size impedes their use in the treatment of solid tumors,which are accessible to objects less than several hundred nanometers. We herein propose an unusual approach involving apH-induced core–shell micelle-to-vesicle transition to prepare ultrasound-sensitive polymeric nanospheres (polymersomes in structure) possessing multiple features, including nanosize, monodispersity, and incorporation of a phase-transitional imaging agent into the aqueous lumen. These features are not achievable via the conventional double-emulsion method for polymersome preparation. The nanospheres were constructed based on a novel triblock copolymer with dual pH sensitivity. The liquid-to-gas phase transition of the imaging agent induced by external low-frequency ultrasound may destroy the nanospheres for a rapid drug release, with simultaneous tissue-penetrating drug delivery inside a tumor. These effects may provide new opportunities for the development of an effective cancer therapy with few adverse effects.

Open image in new window


中文翻译:

pH诱导的胶束-囊泡过渡产生的高度均一的超声敏感纳米球,用于靶向肿瘤的药物递送

尽管具有高回声性的充气微气泡已广泛应用于临床超声检查,但微米级的粒径限制了其在实体瘤治疗中的应用,对于小于几百纳米的物体而言,这些实体瘤是可以进入的。我们在本文中提出了一种不寻常的方法,该方法涉及apH诱导的核-壳胶束到囊泡的转变,以制备具有多种特征的超声敏感的聚合物纳米球(结构中的聚合物体),包括纳米尺寸,单分散性以及将相变成像剂掺入其中水性内腔。通过用于聚合物囊泡制备的常规双乳液方法不能实现这些特征。纳米球是基于具有双重pH敏感性的新型三嵌段共聚物构建的。由外部低频超声诱导的显像剂的液相到气相可能会破坏纳米球,从而迅速释放药物,同时在肿瘤内部同时组织穿透性药物的递送。这些效果可能为开发有效的癌症治疗方法提供新的机会,而几乎没有不良反应。

在新窗口中打开图像
更新日期:2018-08-02
down
wechat
bug