当前位置: X-MOL 学术Proc. Natl. Acad. Sci. U.S.A. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Body weight homeostat that regulates fat mass independently of leptin in rats and mice
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1073/pnas.1715687114
John-Olov Jansson 1 , Vilborg Palsdottir 1 , Daniel A. Hägg 2 , Erik Schéle 1 , Suzanne L. Dickson 1 , Fredrik Anesten 1 , Tina Bake 1 , Mikael Montelius 3 , Jakob Bellman 1 , Maria E. Johansson 1 , Roger D. Cone 4, 5 , Daniel J. Drucker 6 , Jianyao Wu 2 , Biljana Aleksic 2 , Anna E. Törnqvist 2 , Klara Sjögren 2 , Jan-Åke Gustafsson 7 , Sara H. Windahl 2 , Claes Ohlsson 2
Affiliation  

Subjects spending much time sitting have increased risk of obesity but the mechanism for the antiobesity effect of standing is unknown. We hypothesized that there is a homeostatic regulation of body weight. We demonstrate that increased loading of rodents, achieved using capsules with different weights implanted in the abdomen or s.c. on the back, reversibly decreases the biological body weight via reduced food intake. Importantly, loading relieves diet-induced obesity and improves glucose tolerance. The identified homeostat for body weight regulates body fat mass independently of fat-derived leptin, revealing two independent negative feedback systems for fat mass regulation. It is known that osteocytes can sense changes in bone strain. In this study, the body weight-reducing effect of increased loading was lost in mice depleted of osteocytes. We propose that increased body weight activates a sensor dependent on osteocytes of the weight-bearing bones. This induces an afferent signal, which reduces body weight. These findings demonstrate a leptin-independent body weight homeostat (“gravitostat”) that regulates fat mass.

中文翻译:

体重稳态调节剂,独立于大鼠和小鼠的瘦素来调节脂肪量

长时间坐着的受试者肥胖的风险增加,但是站立的抗肥胖作用的机制尚不清楚。我们假设体重有一个体内平衡的调节。我们证明,使用不同重量的胶囊植入腹部或背部的sc后,增加了啮齿动物的负荷,通过减少食物摄入量可逆地降低了生物体重。重要的是,负荷减轻了饮食引起的肥胖症并改善了葡萄糖耐量。已确定的体重稳态调节器可独立于脂肪衍生的瘦素调节人体脂肪量,从而揭示了两个独立的负反馈系统,可进行脂肪量调节。众所周知,骨细胞可以感知骨张力的变化。在这项研究中,在消耗骨细胞的小鼠中失去了增加负荷的减轻体重的作用。我们建议增加体重会激活依赖于负重骨骼的骨细胞的传感器。这会引起传入信号,从而减轻体重。这些发现表明,瘦素独立的体重稳态调节器(“ gravitostat”)可调节脂肪量。
更新日期:2018-01-10
down
wechat
bug