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Diastereoselective Synthesis of Functionalized Indolines Using in situ Generated Allyl Boronic Species
Synlett ( IF 2 ) Pub Date : 2017-12-22 , DOI: 10.1055/s-0036-1589164
Steven Ley 1 , Julio Pastre 2 , José Forni 2 , Shing-Hing Lau 1 , Jian-Siang Poh 1 , Claudio Battilocchio 1
Affiliation  

A new three-component coupling protocol for preparation of functionalized indolines, with a high degree of diastereoselectivity, has been developed. The protocol is based on the in situ homologation of vinyl boronic acids to allylboronic acids, using TMSCHN2 as carbon source, and subsequent coupling reaction with indoles to give 2-substituted indolines. The scope of the method was exemplified in several examples.

中文翻译:

使用原位生成的烯丙基硼物种非对映选择性合成功能化二氢吲哚

开发了一种新的三组分偶联方案,用于制备具有高度非对映选择性的功能化二氢吲哚。该协议基于乙烯基硼酸与烯丙基硼酸的原位同源性,使用 TMSCHN2 作为碳源,随后与吲哚发生偶联反应,得到 2-取代二氢吲哚。该方法的范围在几个例子中举例说明。
更新日期:2017-12-22
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