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Synthesis of Difluoromethylthioesters from Aldehydes
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2018-01-12 , DOI: 10.1002/anie.201710731
Shi-Huan Guo 1 , Xing-Long Zhang 1 , Gao-Fei Pan 1 , Xue-Qing Zhu 1 , Ya-Ru Gao 1 , Yong-Qiang Wang 1
Affiliation  

Difluoromethylthioester compounds are yet another important kind of organofluorine compound and are reported here for the first time. They can be efficiently synthesized from various aldehydes. The synthetic method features mild reaction conditions, good tolerance of functional groups, broad substrate scope, and importantly, no metal is involved in the reaction. The approach has the potential to become an important tool for the late‐stage functionalization of advanced synthetic intermediates, and should have many applications in medicinal chemistry.

中文翻译:

由醛合成二氟甲基硫代酯

二氟甲基硫代酯化合物是有机氟化合物的又一重要种类,在此首次报道。它们可以由各种醛有效地合成。该合成方法具有温和的反应条件,对官能团的良好耐受性,广泛的底物范围,并且重要的是,反应中不涉及金属。该方法有可能成为高级合成中间体后期功能化的重要工具,并应在药物化学中有许多应用。
更新日期:2018-01-12
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