Obesity results from a sustained positive energy balance, occurring when energy intake exceeds energy expenditure. One promising therapeutic strategy to mitigate obesity is the promotion of thermogenesis of brown adipose tissue (BAT) to increase energy expenditure. Cyanidin-3-glucoside (C3G) is an anthocyanin compound widely distributed in human diets. In this study, researchers studied the effect and mechanism of C3G on the prevention and treatment of high-fat and high-fructose diet (HFFD) induced obesity. The study shows that C3G enhances energy expenditure and thermogenic capacity of BAT, protecting mice against HFFD obesity. Further, C3G increases expression of UCP1 and other thermogenic genes in inguinal white adipose tissue (iWAT), as well as in BAT. Results demonstrate that C3G promotes the heat production of BAT and iWAT by increasing mitochondrial biogenesis and function. These findings reveal that C3G activates BAT, which may provide a safe, effective approach to prevent and treat diet-induced obesity.

肥胖源于能量摄入超过能量消耗时持续的正能量平衡。一种减轻肥胖的有前途的治疗策略是促进棕色脂肪组织（BAT）的生热作用，以增加能量消耗。Cyanidin-3-glucoside（C3G）是一种花青素化合物，广泛分布于人类饮食中。在这项研究中，研究人员研究了C3G在预防和治疗高脂和高果糖饮食（HFFD）引起的肥胖症中的作用和机制。研究表明，C3G可提高BAT的能量消耗和产热能力，从而保护小鼠免于HFFD肥胖。此外，C3G增加了腹股沟白脂肪组织（iWAT）和BAT中UCP1和其他产热基因的表达。结果表明，C3G通过增加线粒体的生物发生和功能来促进BAT和iWAT的热量产生。这些发现表明，C3G可激活BAT，这可能为预防和治疗饮食诱发的肥胖症提供安全，有效的方法。