An efficient copper-catalyzed α-C–H amidation of simple ethers with N-(8-quinolyl)amides through C(sp³)–H/N–H cross dehydrogenative coupling was developed. Chelation assistance was employed for the formation of an active copper amide species which can couple with the α-carbon-centered radical generated from simple ethers. This method was applicable to both alkyl and aryl amides as well as various cyclic and acyclic ethers. It also possessed the merit of air and moisture tolerance.

中文翻译：

---

到C简单醚的铜催化的α-C-H的酰胺化（SP ³）-H / N-H横脱氢偶联†

通过C（sp ³）–H / N–H交叉脱氢偶联反应，开发了一种有效的铜催化简单醚与N-（8-喹啉基）酰胺的α-CH酰胺化反应。螯合助剂用于形成活性铜酰胺类物质，该物质可与由简单醚生成的以α-碳为中心的自由基偶合。该方法适用于烷基和芳基酰胺以及各种环状和无环醚。它还具有耐空气和潮湿的优点。