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Gd3+-Doped MoSe2 nanosheets used as a theranostic agent for bimodal imaging and highly efficient photothermal cancer therapy†
Biomaterials Science ( IF 6.6 ) Pub Date : 2017-12-22 00:00:00 , DOI: 10.1039/c7bm00894e
Jiali Pan 1, 2, 3, 4 , Xufeng Zhu 1, 2, 3, 4 , Xu Chen 1, 2, 3, 4 , Yingyu Zhao 1, 2, 3, 4 , Jie Liu 1, 2, 3, 4
Affiliation  

Recently, two dimensional transition metal dichalcogenides (TMDCs) being used as nanomedicine have aroused great interest because of their unique photothermal properties. A simple liquid-phase method was used to prepare gadolinium (Gd3+)-doped molybdenum selenide (MoSe2) nanosheets, and then using poly(ethylene glycol) (PEG) modification on the surface, MoSe2(Gd3+)-PEG nanosheets were obtained which had high stability in physiological solutions and showed no obvious toxicity in vivo. It revealed that Gd3+ used as a paramagnetic material for MoSe2(Gd3+)-PEG provided a strong contrast effect in magnetic resonance imaging, furthermore, the MoSe2 showed strong absorption in the near infrared region, and therefore, MoSe2(Gd3+)-PEG could be used as contrast agent for photoacoustic imaging (PAI). In in vitro experiments, it was found that MoSe2(Gd3+)-PEG could effectively increase the temperature to help kill cancer cells under laser irradiation. In vivo experiments showed that there was an enhanced permeation and retention effect in the tumor after intravenous injection measured using magnetic resonance/photoacoustic (MR/PA) bimodal imaging. After photothermal therapy, a significant suppression effect was achieved for tumors in mice by injection of these nanosheets with laser irradiation. This work emphasized that the simple doped TMDC nanomaterials when combined with treatment and imaging functions achieve a cancer therapy, which will provide a good opportunity for future diagnosis and treatment of cancer.

中文翻译:

Gd 3+掺杂的MoSe 2纳米片用作双峰成像和高效光热癌症治疗的治疗诊断剂

近来,由于其独特的光热性质,二维过渡金属二卤化二氢杀菌剂(TMDC)被​​用作纳米药物引起了人们的极大兴趣。一种简单的液相方法用于制备掺g (Gd 3+)的硒化钼(MoSe 2)纳米片,然后在表面上使用聚乙二醇(PEG)修饰MoSe 2(Gd 3+)-得到的PEG纳米片在生理溶液中具有较高的稳定性,在体内没有明显的毒性。结果表明,Gd 3+被用作MoSe 2(Gd 3+)-PEG在磁共振成像中提供了很强的对比效果,此外,MoSe 2在近红外区域显示出很强的吸收能力,因此MoSe 2(Gd 3+)-PEG可用作光声成像(PAI)的对比剂)。在体外实验中,发现MoSe 2(Gd 3+)-PEG可以有效提高温度,以帮助在激光照射下杀死癌细胞。体内实验表明,使用磁共振/光声(MR / PA)双峰成像测量静脉注射后,肿瘤中的渗透和保留作用增强。在光热疗法之后,通过用激光照射注射这些纳米片,对小鼠中的肿瘤实现了显着的抑制作用。这项工作强调,将简单掺杂的TMDC纳米材料与治疗和成像功能相结合即可实现癌症治疗,这将为以后的癌症诊断和治疗提供良好的机会。
更新日期:2017-12-22
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