In this research, gold nanoparticles modified choline chloride functionalized graphene oxide (AuNPs-ChCl-GO) was synthesized through the assistance of ultrasound and fabricated as a novel bioelectrochemical sensor and utilized for the sensitive detection of meloxicam (MEL). The morphological and structural features of the AuNPs-ChCl-GO were characterized using different techniques including FTIR, TEM, FE-SEM, EDX, and XRD. The modified electrode showed a remarkable improvement in the anodic oxidation activity of MEL due to the enhancement in the current response compared to the bare carbon paste electrode (CPE). The biosensor composition and measurement conditions were optimized using an experimental design. The differential pulse voltammetry (DPVs) exhibited expanded linear dynamic in the range of 9.0 × 10^-9 to 8.5 × 10^-7 M for MEL in Britton-Robinson buffer at pH=4.0 with a detection limit of 2.24 × 10^-9 M. The practical utility of the modified electrode was demonstrated by the accurate detection of MEL in human plasma sample.

在这项研究中，金纳米颗粒改性的胆碱氯化物官能化的氧化石墨烯（AuNPs-ChCl-GO）是在超声的辅助下合成的，并被制成一种新型的生物电化学传感器，并用于美洛昔康（MEL）的灵敏检测。使用不同的技术（包括FTIR，TEM，FE-SEM，EDX和XRD）对AuNPs-ChCl-GO的形态和结构特征进行了表征。相比于裸碳糊状电极（CPE），由于电流响应的增强，改性电极在MEL的阳极氧化活性方面显示出显着改善。使用实验设计优化了生物传感器的组成和测量条件。差分脉冲伏安法（DPV）在9.0×10 ^-9范围内表现出扩展的线性动态pH值为4.0的Britton-Robinson缓冲液中的MEL含量为8.5×10 ^-7 M，检测极限为2.24×10 ^-9M。修饰电极的实际应用通过准确检测人血浆样品中的MEL证明。