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Vitamin A Deficiency Induces Autistic‐Like Behaviors in Rats by Regulating the RARβ‐CD38‐Oxytocin Axis in the Hypothalamus
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-02-19 , DOI: 10.1002/mnfr.201700754
Xi Lai 1, 2 , Xiaofeng Wu 1, 2 , Nali Hou 1, 2 , Shu Liu 1, 2 , Qing Li 1, 2 , Ting Yang 1, 2 , Jingkun Miao 2, 3 , Zhifang Dong 2, 4 , Jie Chen 1, 2 , Tingyu Li 1, 2, 4
Affiliation  

Vitamin A (VA) is an essential nutrient for the development of the brain. We previously found that children with autism spectrum disorder (ASD) have a significant rate of VA deficiency (VAD). In the current study, we aim to determine whether VAD is a risk factor for the generation of autistic‐like behaviors via the transcription factor retinoic acid receptor beta (RARβ)‐regulated cluster of differentiation 38 (CD38)‐oxytocin (OXT) axis.

中文翻译:

维生素A缺乏症通过调节下丘脑中的RARβ-CD38-催产素轴来诱导大鼠自闭症行为

维生素A(VA)是大脑发育必不可少的营养素。我们先前发现,患有自闭症谱系障碍(ASD)的儿童患有严重的VA缺乏症(VAD)。在本研究中,我们旨在通过转录因子视黄酸受体β(RARβ)调控的分化38(CD38)-催产素(OXT)轴簇来确定VAD是否是自闭症样行为发生的危险因素。
更新日期:2018-02-19
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