Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported.

中文翻译：

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通过分批和半连续流动三组分曼尼希反应，由2-氟乙基乙酰乙酸酯和-2-氟丙二酸二甲酯合成β-氟（二羰基）乙胺

报道了2-氟-乙基乙酰乙酸酯或二氟-2-丙二酸丙二酸酯，醛和胺组分之间的多组分曼尼希反应，允许使用间歇和连续流技术方便地合成β-氟（二羰基）乙胺系统。