This study investigated the composition and proportions of fecal microbiota in Sprague-Dawley rats after consuming two genetically modified (GM) corn lines in comparison with the isogenic corn and the AIN93G standard feed for 10 weeks using bar-coded 16S rRNA gene sequencing. As a result, GM corn did not significantly alter the overall health and alpha-diversity of fecal microbiota. Fecal microbiota structures could be separated into noncorn and corn but not non-GM and GM corn subgroups. Both non-GM and GM corn caused the increase in bacterial populations related to carbohydrates utilization, such as Lactobacillus, Barnesiella, and Bifidobacterium, and the reduction in potentially pathogenic populations, such as Tannerella and Moraxellaceae. In conclusion, similar effects on the fecal microbiota were observed after consuming a GM- and non-GM-corn-based diet for long periods. Further studies are warranted to elucidate the functional relevance of the changes in the proportions of bacterial populations in these diets.

中文翻译：

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转基因和等基因玉米品系对Sprague-Dawley大鼠粪便微生物群的调节

这项研究使用条形码16S rRNA基因序列分析了10个星期的同基因玉米和AIN93G标准饲料相比，食用了两种转基因（GM）玉米系后，研究了Sprague-Dawley大鼠粪便微生物群的组成和比例。结果，转基因玉米没有显着改变粪便微生物群的整体健康状况和α-多样性。粪便微生物群结构可以分为非玉米和玉米，但不能分为非转基因和转基因玉米亚组。非转基因和转基因玉米均引起与碳水化合物利用相关的细菌种群的增加，例如乳酸杆菌，Barnesiella和双歧杆菌，以及潜在致病菌种群的减少，例如Tannerella和莫拉菌科。总之，长期食用基于转基因和非转基因玉米的饮食对粪便微生物群的影响相似。有必要进行进一步的研究来阐明这些饮食中细菌种群比例变化的功能相关性。