Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue ofCell Chemical Biology,Lamberto et al. (2017)andPozhidaeva et al. (2017)Pozhidaeva A.Valles G.Wang F.Wu J.Sterner D.E.Nguyen P.Weinstock J.Kumar K.G.S.Kanyo J.Wright D.et al.USP7-specific inhibitors target and modify the enzyme’s active site via distinct chemical mechanisms.Cell Chem. Biol.2017;24(this issue):1501-1512Google Scholarreport important insights into the structural inhibitor-enzyme interplay, lighting the way toward the development of selective inhibitors. Ubiquitin-specific protease 7 is a validated anticancer target; thus, selective USP7 inhibitors are of great interest. In this issue ofCell Chemical Biology,Lamberto et al. (2017)andPozhidaeva et al. (2017)report important insights into the structural inhibitor-enzyme interplay, lighting the way toward the development of selective inhibitors.

中文翻译：

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泛素特异性蛋白酶7选择性抑制的下一步发展

泛素特异性蛋白酶7是经过验证的抗癌靶标；因此，选择性USP7抑制剂引起了极大的兴趣。在本期《细胞化学生物学》中，Lamberto等人。（2017）和Pozhidaeva等人。（2017）Pozhidaeva A.Valles G.Wang F.Wu J.Sterner DENguyen P.Weinstock J.Kumar KGSKanyo J.Wright D.et al.USP7特异性抑制剂可通过不同的化学机制靶向并修饰酶的活性位点。 。Biol.2017; 24（此问题）：1501-1512Google Scholar报告了关于结构性抑制剂与酶相互作用的重要见解，为选择性抑制剂的发展开辟了道路。泛素特异性蛋白酶7是经过验证的抗癌靶标；因此，选择性USP7抑制剂引起了极大的兴趣。在本期《细胞化学生物学》中，Lamberto等人。（2017）和Pozhidaeva等人。