Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries.

中文翻译：

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新生儿脑损伤后，G神经胶质纤维促进神经元迁移和功能恢复。

ial神经胶质（RG）是胚胎神经干细胞（NSC），可产生神经母细胞并提供在胚胎发育过程中充当神经母细胞迁移支架的纤维。尽管它们通常在出生后不久就消失，但在这里我们发现RG纤维可以在受伤的新生小鼠大脑中持续存在，并充当源自产后心室-室下区（V-SVZ）的成神经细胞迁移至病变部位的支架。这种损伤诱导的RG纤维的维持在产后发育期间具有有限的时间窗口，并通过N-钙粘着蛋白介导的细胞与细胞的接触促进RhoA活化，从而促进成神经细胞的定向盐运动。将含有N-钙黏着蛋白的支架移植到受伤的新生儿大脑中同样会促进V-SVZ衍生的神经母细胞的迁移和成熟，导致功能障碍步态行为的改善。这些结果共同表明，RG纤维使产后V-SVZ衍生的成神经细胞向损伤部位迁移，从而增强了新生脑损伤的神经元再生和功能恢复。