Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions†,Organic Chemistry Frontiers

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Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions†
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-12-21 00:00:00 , DOI: 10.1039/c7qo00878c
Romain Rodrigues _{1,

2,

3,

4,

5} , Yanis Lazib _{1,

2,

3,

4,

5} , Julien Maury _{1,

2,

3,

4,

5} , Luc Neuville _{1,

2,

3,

4,

5} , David Leboeuf _{3,

4,

6,

7,

8} , Philippe Dauban _{1,

2,

3,

4,

5} , Benjamin Darses _{1,

2,

3,

4,

5}

Affiliation

Dirhodium(II)-catalyzed nitrene transfers have been used to prepare a novel synthetic platform bearing the triamino moiety present in pactamycin, jogyamycin and cranomycin. Catalytic intramolecular C(sp³)–H amination and alkene aziridination reactions, the latter followed by a nucleophilic aziridine ring opening, are the key steps of this strategy.

中文翻译：

使用铑（ii）催化的烯烃叠氮化和C（sp ³）-H氨基化反应制备pactamycin类似物的方法†

Dirhodium（II）催化的腈转移已用于制备新型的合成平台，该平台带有在pactamycin，jogyamycin和cranomycin中存在的三氨基部分。催化分子内C（sp ³）-H胺化和烯烃叠氮化反应，随后是亲核氮丙啶开环反应，是该策略的关键步骤。

更新日期：2017-12-21

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