A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.

中文翻译：

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轻度钙催化贝克曼重排

已经实现了轻度钙催化的贝克曼重排，这消除了与转化相关的更传统的苛刻反应条件。已表明该催化剂体系对与天然产物合成和药物化学有关的多种官能团具有耐受性，并且还研究了该反应的合成效用。进行了初步的机械研究，以了解传入亲核试剂的性质，并描述了可能的反应途径。