Sugarcane (Saccharum officinarum L.), which is one of the most important sources of sugar, is also rich in polyphenolic compounds. In this study, polyphenols from sugarcane were extracted, and the dominant component was characterized quantitatively via HPLC to be (−)-epicatechin. Fibrosis occurs in many organs and is associated with severe tissue damage. Liver fibrosis is the excessive accumulation of extracellular matrix proteins and advanced liver fibrosis, resulting in cirrhosis, liver failure and portal hypertension. Thus, the prevention and treatment of liver fibrosis is urgent. Therefore, we further investigated the protective effect of sugarcane polyphenol extract (SPE) on carbon tetrachloride-induced liver fibrosis in rats and observed that SPE (20 or 50 mg kg⁻¹) improved the serum GOT (glutamic oxaloacetic transferase) and GPT (glutamic pyruvate transaminase) levels and decreased the expression of α-smooth muscle actin (α-SMA) in liver tissues. The mechanistic study showed that in transforming growth factor β1(TGF-β1)-induced hepatic stellate cells (HSCs), SPE attenuated the phosphorylation of p38 and JNK1/2 and down-regulated the expression of α-SMA. Collectively, SPE mitigated carbon tetrachloride-induced liver fibrosis in rats and its mechanism may be related to the p38 and JNK signalling pathways.

中文翻译：

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在大鼠中多酚的富集的甘蔗提取物的抗纤维化活性通过抑制p38和JNK的磷酸化的†

甘蔗（Saccharum officinarum L.）是糖的最重要来源之一，也富含多酚类化合物。在这项研究中，从甘蔗中提取多酚，并通过HPLC定量分析了其主要成分为（-）-表儿茶素。纤维化发生在许多器官中，并与严重的组织损伤有关。肝纤维化是细胞外基质蛋白的过度积累和晚期肝纤维化，从而导致肝硬化，肝衰竭和门脉高压。因此，肝纤维化的预防和治疗迫在眉睫。因此，我们进一步研究了甘蔗多酚提取物（SPE）对四氯化碳诱导的大鼠肝纤维化的保护作用，并观察到SPE（20或50 mg kg ^-1）改善了血清GOT（谷氨酸草酰乙酸转移酶）和GPT（谷氨酸丙酮酸转氨酶）的水平，并降低了肝组织中α-平滑肌肌动蛋白（α-SMA）的表达。机理研究表明，在转化生长因子β1（TGF-β1）诱导的肝星状细胞（HSCs）中，SPE减弱了p38和JNK1 / 2的磷酸化，并下调了α-SMA的表达。SPE共同减轻了大鼠四氯化碳诱导的肝纤维化，其机制可能与p38和JNK信号通路有关。